Effects of high pressure on platelet aggregation in vitro. [erratum appears in Undersea Biomed Res 1987 Jan;14(1):preceding 1]

PubMed Citation: 3085303
Abstract: An apparatus which enables aggregating agents to be added to a stirred suspension of platelets subjected to a pressure of up to 600 ATA is described. The ensuing aggregation reaction is monitored optically. The pressure is applied with helium; data are presented that indicate the effects are mainly attributable to hydrostatic pressure. The aggregation of human platelets induced by ADP was reversibly inhibited by pressure in the 1-270 ATA range. The second phase of aggregation was blocked by 65 ATA; the rate of first phase aggregation was reduced but the time to respond to ADP was not affected. Comparable pressures also affected collagen and arachidonate-induced aggregation. The time to respond to these aggregating agents was prolonged and both the rate and the degree of aggregation were reduced by pressure.
Journal Issue & Number: Undersea Biomedical Research 13(1), 63-75. (1986)
Rights: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
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