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Investigating the Relationship Between Heart Rate, QT, and QTc in Alternating Hemiplegia of Childhood and Other ATP1A3-Associated Phenotypes

Descripción:

Background: Alternating hemiplegia of childhood (AHC) is a rare condition most frequently caused by mutations in ATP1A3, encoding for the alpha-3 subunit of Na+/K+-ATPase, and D801N is the most common variant. Individuals with ATP1A3-D801N have...

Fecha de Creacion:

August 1-2, 2024
Evaluating Immunoproteasome Inhibition in Murine Cardiac Transplant Recipients: Can a Novel Therapeutic with Enhanced Specificity Reduce Toxicity and Prevent Antibody-Mediated Damage?

Descripción:

Objective: Cardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is the leading cause of cardiac transplant failure. Proteasome inhibitors (PIs) are utilized to treat AMR; however,...

Fecha de Creacion:

August 1-2, 2024
A Randomized Controlled Trial of Combined Spinal Epidural versus Dural Puncture Epidural Techniques for Labor Analgesia

Descripción:

Summary Background The dural puncture epidural technique (DPE) is a modification of the combined spinal epidural technique (CSE). Data comparing the two techniques are limited. We performed this randomised study to compare the quality of...

Fecha de Creacion:

August 1-2, 2024
A Case-Control Study of ALS in Eastern North Carolina: Investigating the Role of Algae and Pesticides in a Region of High ALS Mortality

Descripción:

Background: The development of amyotrophic lateral sclerosis (ALS) has been associated with both genetic and environmental factors. In particular, there is concern that exposure to toxins produced by cyanobacterial harmful algal blooms (CHABs) and...

Fecha de Creacion:

August 1-2, 2024
Concerns and opinions of people currently or previously on oral and long-acting injectable forms of HIV preexposure prophylaxis (PrEP)

Descripción:

Background Long acting injectable (LAI) preexposure prophylaxis (PrEP) has the potential to increase PrEP uptake and adherence. However, the majority of studies investigating opinions about LAI PrEP were theoretical, done prior to its approval....

Fecha de Creacion:

August 1-2, 2024
Relative Clinical Benefit Of Biventricular Pacing In Cardiac Amyloidosis

Descripción:

Background: Cardiac amyloidosis (CA) is associated with high rates of intrinsic conduction disease. Patients with CA and cardiac implantable electronic devices (CIED) have demonstrated an eventual reliance on ventricular pacing, regardless of...

Fecha de Creacion:

August 1-2, 2024
Epidemiology and Outcomes of Congenital Hypothyroidism of Prematurity in Very-Low-Birth-Weight Infants

Descripción:

Background: Congenital hypothyroidism is the most common congenital endocrine disorder, and is one of the most common and preventable causes of intellectual disability. Preterm infants with low birth weights are more likely to develop congenital...

Fecha de Creacion:

August 1-2, 2024
Understanding Antenatal Depression Management in the Outpatient High-Risk Obstetrics Care Setting — Collaborative Care as a Solution

Descripción:

Background: High-risk pregnancies are associated with a higher risk of antenatal and postpartum depression. ACOG recommends early perinatal depression screening, and SSRIs as first-line pharmacotherapy with follow-up using validated screening...

Fecha de Creacion:

August 1-2, 2024
The Contested History of Psychogenic Non-Epileptic Seizures

Descripción:

Background: One of the most challenging groups of patients seen by neurologists today are those experiencing convulsive, seizure-like episodes – but in whom no abnormal neurologic activity is found. Psychogenic non-epileptic seizures sit at the...

Fecha de Creacion:

August 1-2, 2024
Immuno-informatic Approaches to Identifying Variant-Transcendent Naturally-Acquired Protection against Plasmodium falciparum

Descripción:

Background: Plasmodium falciparum antigenic diversity compromises the development of lasting immunity. Currently available vaccines for malaria contain a single sequence of P. falciparum circumsporozoite protein (CSP), and protection following...

Fecha de Creacion:

August 1-2, 2024

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