Evaluation of pain often relies on subjective patient reported outcomes (PROs) such as the Brief Pain Inventory. Supplementing such measures with objective endpoints can provide a deeper assessment of acute and chronic pain. In the present study,...
Background: The distribution of amyotrophic lateral sclerosis (ALS) across the world appears to be uneven, which may in part be explained by environmental factors. β-methylamino-L-alanine (BMAA), a neurotoxin produced by cyanobacteria, and...
Background: Chronic lower back pain (LBP) is a leading cause of disability and economic burden worldwide. Despite numerous treatment modalities, patient outcomes remain poor. Identifying the correct treatment for a given patient remains presenting...
Laser interstitial thermal therapy (LITT) is an emerging modality for hyperthermic ablation of brain tumors. Hyperthermia-induced tumor coagulative necrosis may serve as a source of neoantigen for T-cell priming and a subsequent anti-tumor immune...
Background: Gliomas are the most common malignant primary brain tumor. Genomic characterization is necessary for diagnosis and treatment decisions, for which the brain is biopsied and can lead to delays in care, morbidity, and mortality. Here, we...
Background:
Multiple sclerosis (MS) is more prevalent in female patients and is frequently diagnosed during reproductive years. Patients with multiple sclerosis (PwMS) have a decreased risk of relapse during pregnancy and this risk increases...