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Filtern nach: Sammlung 55th Annual Duke School of Medicine Student Research Symposium Research Type Lab Based

Validation of Hypoxic Red Blood Cell Storage Procedure and Interrogation of its Vasoregulatory Effects

Beschreibung:	Background: Red blood cells (RBCs), in addition to carrying oxygen, generate and export vasoregulatory mediators as a function of their metabolic context. S- nitrosothiol (SNO) is exported to effect hypoxic vasodilation, a fundamental vascular...
Datum erstellt:	August 1-2, 2024

Generation of antibodies for the diagnosis of acute and chronic Chagas Disease using phage display technology

Beschreibung:	Caused by the parasite Trypanosoma cruzi, Chagas disease is one of the most neglected tropical diseases in the world and poses a significant burden to the estimated eight million people living with disease. As primary infection is largely...
Datum erstellt:	August 1-2, 2024

Evaluating Immunoproteasome Inhibition in Murine Cardiac Transplant Recipients: Can a Novel Therapeutic with Enhanced Specificity Reduce Toxicity and Prevent Antibody-Mediated Damage?

Beschreibung:	Objective: Cardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is the leading cause of cardiac transplant failure. Proteasome inhibitors (PIs) are utilized to treat AMR; however,...
Datum erstellt:	August 1-2, 2024

Immuno-informatic Approaches to Identifying Variant-Transcendent Naturally-Acquired Protection against Plasmodium falciparum

Beschreibung:	Background: Plasmodium falciparum antigenic diversity compromises the development of lasting immunity. Currently available vaccines for malaria contain a single sequence of P. falciparum circumsporozoite protein (CSP), and protection following...
Datum erstellt:	August 1-2, 2024

Improving Microbial Keratitis Artificial Intelligence Screening Tools Constrained by Limited Data Using Synthetic Generation of Slit Lamp Photos

Beschreibung:	Background: Artificial Intelligence (AI) models, like those used in diabetic retinopathy screening, require large amounts of data to train. Models for diseases with limited public data like microbial keratitis (MK), a top five cause of blindness...
Datum erstellt:	August 1-2, 2024

Role of Regulatory T-Cells in the Development of Post-Traumatic Osteoarthritis

Beschreibung:	Traumatic etiology is implicated in up to 12% of the cases of osteoarthritis in the United States. This type of arthritis, termed post traumatic osteoarthritis (PTOA), has been proposed to be mediated in part through an imbalance in inflammatory...
Datum erstellt:	August 1-2, 2024

Neighborhood Deprivation and Quality of Comprehensive Diabetes Care: Findings from a National Study of Medicare Advantage

Beschreibung:	Background: Neighborhood socioeconomic deprivation is a known contributor to health inequities, though its impact on the care of people with diabetes is not well characterized. Understanding the contribution of systemic forces that drive disparate...
Datum erstellt:	August 1-2, 2024

Neural and Perceptual Correlates of Eye-Movement Related Eardrum Oscillations – a New Window into Brain Function?

Beschreibung:	Cochlear and middle ear efferents modulate sensory information in the hearing system, shaping auditory waveforms and refining sound perception. These efferent pathways innervate the middle ear muscles and cochlear outer hair cells; eardrum...
Datum erstellt:	August 1-2, 2024

Molecular Determinants of Sarcoidosis

Beschreibung:	Background: Sarcoidosis is a multi-system inflammatory disease characterized by noncaseating granulomas, for which the current mainstay of treatment is steroids and/or other immunosuppressing agents. There is a need to better understand the...
Datum erstellt:	August 1-2, 2024

Mesenchymal stem cell exosomes exhibit anti-inflammatory effects on the ocular surface in a murine model of Stevens Johnson Syndrome and allergic eye disease

Beschreibung:	Background: Targeted immunotherapies are needed in inflammatory ocular surface diseases as an alternative to the blanket immunosuppression of steroids, which can cause a host of undesirable side-effects. Mesenchymal stem cell-derived exosomes...
Datum erstellt:	August 1-2, 2024