Background: Amyotrophic lateral sclerosis (ALS) is an adult-onset, relentless and almost universally fatal motor neuron disease. Rarely, patients with clinically proven ALS experience long, sustained improvement in their symptoms. These ALS “reversals”...
Background
Neurosurgical resection of tumors requires discernment of tumor from healthy tissue. Endogenous fluorophores exist in different concentrations in tissue enabling the classification of tissue type via excitation with a low power laser. The...
Funding for this work was provided by Duke Global Health Institute and Duke Global Neurosurgery and Neurology.
Background: Traumatic brain injury (TBI) accounts for the majority of Uganda’s neurosurgical disease burden; however, invasive...
Background: While Kambin’s triangle has become an ever more important anatomic window given its proximity to the nerve root, there have been limited studies examining the effect of disease on the corridor. Recent studies have begun implementing 3D...
Background: Mouse digit tip (MDT) regeneration represents an important laboratory model for studying complex tissue regeneration in mammals. Though modest in comparison to its appendage regeneration counterparts in zebrafish and salamander, MDT...
The APOE4 allele is the most common genetic risk factor for late-onset Alzheimer’s Disease (AD), and it is thought to contribute via pathways such as neuroinflammation and exacerbation of underlying AD pathology. An apoE mimetic peptide called CN-105...
INTRODUCTION: The urogenital microbiome, including microbes in the urinary bladder and vagina, demonstrates variations that are linked to aging. While prior studies have shown how the composition of the vaginal microbiome changes after menopause, less...
Background: Amyotrophic lateral sclerosis (ALS) prognosis is poor, but not all patients progress at equal rates. There are slow progressors, fast progressors, and even the rare reversals of ALS. Interestingly, increasing evidence suggests the...
Background: Peripheral nerve injury is a rare, but potentially devastating complication following shoulder arthroplasty, with patients possibly having worse patient-reported outcomes, residual neuropathic pain, sensorimotor deficits, and increased...
Background: Therapy de-escalation may be appropriate for select older patients with breast cancer. With the increasing utilization of genomic assays, such as the Oncotype DX Recurrence Score (RS), the relevance of anatomic staging has been questioned....