Background and Hypothesis
Cutaneous wound healing is a complex process that is typically characterized by significant inflammation and fibrosis, culminating in the formation of a scar. Improper wound healing can lead to complications, including...
Background: Cartilage damage is challenging to treat due to its limited self-healing capacity caused by its avascular and aneural nature. However, 3D tissue engineering approaches that utilize biomaterials, additives, and cells offer a promising...
Background BRAF mutations are common in melanoma, with more than 50% harboring activating BRAF mutations. Though BRAF inhibitors are highly efficacious for nearly half of patients with this BRAF-mutant melanoma, many developing secondary resistance...
Laser interstitial thermal therapy (LITT) is an emerging modality for hyperthermic ablation of brain tumors. Hyperthermia-induced tumor coagulative necrosis may serve as a source of neoantigen for T-cell priming and a subsequent anti-tumor immune...
Background: A primary focus of regenerative medicine is to understand the cellular mechanisms
governing tissue regeneration across various species. Mammals generally possess a restricted
regenerative capacity compared to species like zebrafish or...
Objectives: Endothelial colony-forming cells (ECFCs) in circulating blood represent an attractive cell source for cellularizing engineered valve scaffolds that may function as living valve replacements with durability and growth potential. In other...
Background: Thoracic aortic pathology most commonly reviewed at our institution includes aortic aneurysms, acute dissection and acute aortitis, all which are associated with distinct histologic and morphologic features. Spatial transcriptomics enables...
Background: Red blood cells (RBCs), in addition to carrying oxygen, generate and export vasoregulatory mediators as a function of their metabolic context. S- nitrosothiol (SNO) is exported to effect hypoxic vasodilation, a fundamental vascular reflex...
Caused by the parasite Trypanosoma cruzi, Chagas disease is one of the most neglected tropical diseases in the world and poses a significant burden to the estimated eight million people living with disease. As primary infection is largely asymptomatic,...
Objective: Cardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is the leading cause of cardiac transplant failure. Proteasome inhibitors (PIs) are utilized to treat AMR; however,...