Background: Red blood cells (RBCs), in addition to carrying oxygen, generate and export vasoregulatory mediators as a function of their metabolic context. S- nitrosothiol (SNO) is exported to effect hypoxic vasodilation, a fundamental vascular...
Caused by the parasite Trypanosoma cruzi, Chagas disease is one of the most neglected tropical diseases in the world and poses a significant burden to the estimated eight million people living with disease. As primary infection is largely...
Objective: Cardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is the leading cause of cardiac transplant failure. Proteasome inhibitors (PIs) are utilized to treat AMR; however,...
Background:
Plasmodium falciparum antigenic diversity compromises the development of lasting immunity. Currently available vaccines for malaria contain a single sequence of P. falciparum circumsporozoite protein (CSP), and protection following...
Background: Artificial Intelligence (AI) models, like those used in diabetic retinopathy screening, require large amounts of data to train. Models for diseases with limited public data like microbial keratitis (MK), a top five cause of blindness...
Traumatic etiology is implicated in up to 12% of the cases of osteoarthritis in the United States. This type of arthritis, termed post traumatic osteoarthritis (PTOA), has been proposed to be mediated in part through an imbalance in inflammatory...
Background: Neighborhood socioeconomic deprivation is a known contributor to health inequities, though its impact on the care of people with diabetes is not well characterized. Understanding the contribution of systemic forces that drive disparate...
Cochlear and middle ear efferents modulate sensory information in the hearing system, shaping auditory waveforms and refining sound perception. These efferent pathways innervate the middle ear muscles and cochlear outer hair cells; eardrum...
Background: Sarcoidosis is a multi-system inflammatory disease characterized by noncaseating granulomas, for which the current mainstay of treatment is steroids and/or other immunosuppressing agents. There is a need to better understand the...
Background: Targeted immunotherapies are needed in inflammatory ocular surface diseases as an alternative to the blanket immunosuppression of steroids, which can cause a host of undesirable side-effects. Mesenchymal stem cell-derived exosomes...