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Filtering by: Research Type Lab Based Study Program Anesthesiology, Surgery, and Environmental Physiology Study Program (ASEP)

Validation of Hypoxic Red Blood Cell Storage Procedure and Interrogation of its Vasoregulatory Effects

Description/Abstract:	Background: Red blood cells (RBCs), in addition to carrying oxygen, generate and export vasoregulatory mediators as a function of their metabolic context. S- nitrosothiol (SNO) is exported to effect hypoxic vasodilation, a fundamental vascular...
Date:	August 1-2, 2024

Evaluating Immunoproteasome Inhibition in Murine Cardiac Transplant Recipients: Can a Novel Therapeutic with Enhanced Specificity Reduce Toxicity and Prevent Antibody-Mediated Damage?

Description/Abstract:	Objective: Cardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is the leading cause of cardiac transplant failure. Proteasome inhibitors (PIs) are utilized to treat AMR; however,...
Date:	August 1-2, 2024

Integrated Diaphragmatic Function, Chemosensitivity, and Endurance in Exercising Divers

Description/Abstract:	Background: While exercising underwater, divers experience increased ventilatory load which can predispose them to respiratory muscle fatigue and hypercapnia. Hypercapnic ventilatory response (HCVR) is a highly variable measure of the...
Date:	August 1-2, 2024

Heterotopic Liver Transplant: a Novel Rat Model for Acute Cellular Rejection

Description/Abstract:	Background: Laboratory rats are used as the standard animal model for studying liver transplantation (LT) due to their size facilitating microsurgery and easy handling, genome similarity to humans, and post-LT immune responses being similar to...
Date:	August 1-2, 2024