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Validation of Hypoxic Red Blood Cell Storage Procedure and Interrogation of its Vasoregulatory Effects

Description/Abstract:	Background: Red blood cells (RBCs), in addition to carrying oxygen, generate and export vasoregulatory mediators as a function of their metabolic context. S- nitrosothiol (SNO) is exported to effect hypoxic vasodilation, a fundamental vascular...
Date:	August 1-2, 2024

Generation of antibodies for the diagnosis of acute and chronic Chagas Disease using phage display technology

Description/Abstract:	Caused by the parasite Trypanosoma cruzi, Chagas disease is one of the most neglected tropical diseases in the world and poses a significant burden to the estimated eight million people living with disease. As primary infection is largely...
Date:	August 1-2, 2024

Immuno-informatic Approaches to Identifying Variant-Transcendent Naturally-Acquired Protection against Plasmodium falciparum

Description/Abstract:	Background: Plasmodium falciparum antigenic diversity compromises the development of lasting immunity. Currently available vaccines for malaria contain a single sequence of P. falciparum circumsporozoite protein (CSP), and protection following...
Date:	August 1-2, 2024

Improving Microbial Keratitis Artificial Intelligence Screening Tools Constrained by Limited Data Using Synthetic Generation of Slit Lamp Photos

Description/Abstract:	Background: Artificial Intelligence (AI) models, like those used in diabetic retinopathy screening, require large amounts of data to train. Models for diseases with limited public data like microbial keratitis (MK), a top five cause of blindness...
Date:	August 1-2, 2024

Neighborhood Deprivation and Quality of Comprehensive Diabetes Care: Findings from a National Study of Medicare Advantage

Description/Abstract:	Background: Neighborhood socioeconomic deprivation is a known contributor to health inequities, though its impact on the care of people with diabetes is not well characterized. Understanding the contribution of systemic forces that drive disparate...
Date:	August 1-2, 2024

Neural and Perceptual Correlates of Eye-Movement Related Eardrum Oscillations – a New Window into Brain Function?

Description/Abstract:	Cochlear and middle ear efferents modulate sensory information in the hearing system, shaping auditory waveforms and refining sound perception. These efferent pathways innervate the middle ear muscles and cochlear outer hair cells; eardrum...
Date:	August 1-2, 2024

Mesenchymal stem cell exosomes exhibit anti-inflammatory effects on the ocular surface in a murine model of Stevens Johnson Syndrome and allergic eye disease

Description/Abstract:	Background: Targeted immunotherapies are needed in inflammatory ocular surface diseases as an alternative to the blanket immunosuppression of steroids, which can cause a host of undesirable side-effects. Mesenchymal stem cell-derived exosomes...
Date:	August 1-2, 2024

Synergizing hyperthermia and immunotherapy in intracranial tumors

Description/Abstract:	Laser interstitial thermal therapy (LITT) is an emerging modality for hyperthermic ablation of brain tumors. Hyperthermia-induced tumor coagulative necrosis may serve as a source of neoantigen for T-cell priming and a subsequent anti-tumor immune...
Date:	August 1-2, 2024

Spatial Transcriptomics of Thoracic Aortic Pathology

Description/Abstract:	Background: Thoracic aortic pathology most commonly reviewed at our institution includes aortic aneurysms, acute dissection and acute aortitis, all which are associated with distinct histologic and morphologic features. Spatial transcriptomics...
Date:	August 1-2, 2024

Integrated Diaphragmatic Function, Chemosensitivity, and Endurance in Exercising Divers

Description/Abstract:	Background: While exercising underwater, divers experience increased ventilatory load which can predispose them to respiratory muscle fatigue and hypercapnia. Hypercapnic ventilatory response (HCVR) is a highly variable measure of the...
Date:	August 1-2, 2024