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Knechtle, Stuart
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Immunology
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Evaluating Immunoproteasome Inhibition in Murine Cardiac Transplant Recipients: Can a Novel Therapeutic with Enhanced Specificity Reduce Toxicity and Prevent Antibody-Mediated Damage?
Description/Abstract:
Objective: Cardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is the leading cause of cardiac transplant failure. Proteasome inhibitors (PIs) are utilized to treat AMR; however,...
Date:
August 1-2, 2024
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55th Annual Duke School of Medicine Student Research Symposium
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Creator
Schwalb, Allison
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Mentor
Knechtle, Stuart
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1
Contributor
Anwar, Imran
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Belloni, Rafaela
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DeLaura, Isabel
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Glass, Carolyn
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Kwun, Jean
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Subject
Antibodies
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Chronic organ rejection
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Heart transplant
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Immunology
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Vascular injury
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No thank you
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Research Type
Lab Based
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Study Program
Anesthesiology, Surgery, and Environmental Physiology Study Program (ASEP)
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Year
2024
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